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مطالعات کوهورت  Cohort Studies
Involves comparing disease incidence over time between groups (cohorts) found to differ on their exposure to a factor of interest. Two types: • prospective  • retrospective prospective cohort study begins with the selection of two groups of non-diseased animals: • exposed to a factor postulated to cause a disease • unexposed to a factor postulated to cause a disease retrospective cohort study starts when all of the disease cases have been identified. History of each study participant is carefully evaluated for evidence of exposure to the agent under investigation
Cohort studies
Schematic diagram of a prospective and retrospective cohort study
• You can examine multiple outcomes for a single exposure, • Are very useful in examining rare exposures • Provide estimates of the absolute incidence of disease in exposed and non-exposed individuals, • Temporal sequence is logical E xposure status is recorded before disease has been identified • Provides unambiguous information about whether exposure preceded disease. • Well-suited for studying rare exposures. • Relative number of exposed and non-exposed persons in the study need not necessarily reflect true exposure prevalence in the population at large. Subjects are monitored over time for disease occurrence,
Advantages of Cohort studies

 

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