چکیده : 

Electrospinning process has been widely used to produce nanofibers from polymer blends.

Poly (vinyl alcohol) (PVA) and chitosan (CS) have numerous biomedical applications such as

wound healing and tissue engineering. Nanofibers of CS/PVA have been prepared by many

works, however, a complete physic-chemical and mechanical characterization as well as cell

behavior has not been reported. In this study, PVA and CS/PVA blend solutions in acetic acid

70% with different volume ratios (30/70, 50/50 and 70/30) were electrospun in constant

electrospinning process parameters. The structure and morphology of nanofibrous mats

were characterized by SEM, FTIR and XRD methods. The best nanofibrous mat was achieved

from the CS/PVA 30/70 blend solution regarding the electrospinning throughput. The

dynamic mechanical thermal analysis (DMTA) of PVA and CS/PVA 30/70 nanofibrous mats

were measured which were not considered in the previous studies. DMTA results in

accordance to the DSC analysis, approved the partial compatibility between the two

polymers, while a single glass transition temperature was not observed for the blend. The

tensile strength of PVA and CS/PVA nanofibers were also reported. Results of cell behavior

study indicated that the heat stabilized nanofibrous mat CS/PVA 30/70 was able to support

the attachment and proliferation of the fibroblast cells.