چکیده :

Background: Obesity is one of the main causes of preventable death. Complications of

childhood obesity include cardiovascular risk, impaired glucose tolerance, type 2 diabetes

mellitus, and acanthosis nigricans (AN; associated with obesity as a manifestation of

cutaneous insulin resistance). An interaction between AN and obesity as well as a detailed

mechanism for the pre- and co-obesity appearance of AN in children are still to be

revealed.

Purposes: This research tries to assess involvement of the insulin/insulin-like growth factor

(IGF) receptor pathway in childhood pre- and co-obesity AN via a study of the association of

polymorphisms of the INSR, IRS1, and IGF1R genes with pre- and co-obesity AN.

Methods: In total, 99 children with pre- and co-obesity AN and 100 healthy controls were

genotyped and analyzed by the polymerase chain reaction-restriction fragment length

polymorphism method.

Results: Intergroup frequency differed starkly for INSR His1085His and IGF1R IVS7-20, but

not in the IRS1 Ala804Ala or IGF1R Thr766Thr genotypes. The T allele of INSR His1085His

and C allele of IGF1R IVS7-20 both conferred a starkly( p¼0.04 and 2.84E-6 ¼ 2.84 x 106,

respectively)higher risk for AN.

Conclusion: The above findings suggest that certain genetic variants in insulin/insulin-like

growth factor (IGF) receptor pathway might be correlated with the appearance of AN prior

to or concurrent with obesity, and also reveal the insulin/IGF receptor pathway as crucial in

pre- and co-obesity AN.